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A spell cast from HP may work normally, but more often than not the plot demands that the use of life itself must amplify the effect dramatically. The effects of this on the magic itself vary as well.

Casting from hit points in a way that causes irreversible/cumulative damage to the caster is Power Degeneration, while fueling a Super Mode from hit points is a Heroic RRoD. At its mildest, casting from HP leads to immediate physical effects such as fatigue or a Psychic Nosebleed. Whether this is cut from physical longevity or some kind of cosmic clock depends on the series.

Lesser versions may result in a decreased lifespan, which is typically given in round numbers such as years. When done by multiple casters at once, this qualifies as a Combined Energy Attack. In extreme cases, a spell cast from HP may cost the caster their life, resulting in a Heroic Sacrifice this is often done for the purpose of Taking You with Me. The cost of the life energy thus expended will vary. What do you do? Spend your own Life Energy on the spell in place of whatever would normally power it. You've just run out of your source of magic, whether it's Magic Points or other Phlebotinum, and you desperately need to cast a spell to save the day.

Kain, about his Blood Gout spell, Legacy of Kain: Blood Omen

Best combo for dragon of the month dragon mania legends